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pentobarbital will reduce the extent or outcome of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic outcome of elbasvir/grazoprevir might be lowered if coadministered with powerful CYP3A inducers and it is for that reason contraindicated.Spinal block: A spinal block is more powerful tha